Hyperbaric Oxygen Therapy (HBOT) For Mental Health

Hyperbaric Oxygen Therapy (HBOT) is a medical treatment where you breathe concentrated oxygen inside a pressurized chamber, allowing your bloodstream and tissues to receive far more oxygen than under normal conditions. At Mind Spa Denver, HBOT is delivered in a 2.0 ATA hyperbaric chamber, a therapeutic pressure used in clinical research to support neurological healing and reduce inflammation in the brain and body.
How Does It Work?
When you breathe pure oxygen under pressure, both your red blood cells and plasma carry significantly more oxygen to areas affected by injury, inflammation, or impaired blood flow. This oxygen surplus can reduce neuroinflammation, stimulate stem cell production and neurogenesis, enhance mitochondrial function and ATP production, support new blood vessel growth (angiogenesis), and strengthen detoxification and immune responses involved in healing.
For patients with traumatic brain injury (TBI) or post-traumatic stress disorder (PTSD), HBOT helps restore function by accelerating the brain’s natural healing processes. Brain imaging studies even show structural and metabolic improvements in areas affected by trauma.
Who is HBOT for?
HBOT at Mind Spa Denver is designed for people who have not responded fully to conventional treatments for traumatic brain injury (TBI), post‑traumatic stress disorder (PTSD), concussion and post‑concussion syndrome, and depression or anxiety related to brain injury or chronic stress. It is particularly relevant for veterans, first responders, and athletes, as well as anyone with lingering cognitive, emotional, or physical symptoms after brain trauma.
What Is the Patient Experience Like?
Each HBOT session takes place in a comfortable, 2.0 ATA chamber where you sit back, relax, and breathe normally while the chamber gradually pressurizes. Sessions last about 60 minutes, are typically scheduled in a series of 20–40 treatments depending on clinical needs, and are generally well‑tolerated with only mild, infrequent side effects such as temporary ear pressure or fatigue.
What results can patients expect?
Over a decade of clinical research suggests that HBOT can contribute to improved memory, focus, mood, sleep, and emotional regulation, while reducing anxiety, depression, and other persistent post‑injury symptoms. When completed as a full course and combined with complementary treatments like TMS, ketamine infusion therapy, and psychotherapy, many patients report substantial symptom relief within a few weeks and a lower risk of long‑term disability after TBI.
What results can patients expect?
Over a decade of clinical research suggests that HBOT can contribute to improved memory, focus, mood, sleep, and emotional regulation, while reducing anxiety, depression, and other persistent post‑injury symptoms. When completed as a full course and combined with complementary treatments like TMS, ketamine infusion therapy, and psychotherapy, many patients report substantial symptom relief within a few weeks and a lower risk of long‑term disability after TBI.
Patients who complete a full course of HBOT, especially when combined with TMS, ketamine infusion therapy, and psychotherapy, patients often report full symptom remission within 2–3 weeks. For many, it’s the breakthrough they’ve been waiting for.
How to get started
If you are ready to explore a science‑backed, integrative approach to healing your brain and reclaiming your life, Mind Spa Denver’s team can guide you through whether HBOT is appropriate for your specific history and goals. Complete our secure new patient forms, and a member of the team will reach out to schedule a personalized consultation and treatment plan.
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Selected Clinical References:
- Harch & Fogarty, Medical Gas Research, 2018
- Boussi-Gross et al., PLoS ONE, 2013
- Hadanny & Efrati, Expert Rev Neurother, 2016
- Sackheim et al., Am J Psychiatry, 2022
- Tal et al., Frontiers in Psychology, 2021





